Evaluation of Sustained-release Dosage Form with Novel Metformin Salts
نویسندگان
چکیده
منابع مشابه
Formulation and In vitro Evaluation of Sustained Release Dosage Form with Taste Masking of Metformin Hydrochloride
An attempt was made to sustain the release of metformin HCl as well as to mask the bitter taste by complexation technique using strong cation-exchange resins, indion 244 and indion 264. The drug loading onto ion-exchange resin was optimized for mixing time, activation, effect of pH, mode of mixing, ratio of drug:resin and temperature. The resinate was evaluated for micromeritic properties, tast...
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To examine newly developed single-unit of oral sustained release dosage form Simvastatin (SS) have been prepared by the wet granulation method. The hydrophilic matrix was prepared with xanthan gum with additives MCC PH101. On the in vitro drug release was studied. The studies indicated that the drug release can be modulated by varying the concentration of the polymer and fillers. Various pharma...
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sustained release oral delivery systems are designed to achieve therapeutically effective concentrations of drug in the systemic circulation over an extended period of time. the purpose of the present investigation was to design and evaluate sustained release matrix tablets of nifedipine, a poorly water soluble drug, employing hydroxypropyl methyl cellulose ( hpmc) and ethyl cellulose ( ec) as ...
متن کاملDevelopment and Evaluation of Thymol Microparticles Using Cellulose Derivatives as Controlled Release Dosage Form
Thymol, an important and advantageous component of many essential oils, has been applied as an antimicrobial agent in animals. To increase the duration of action of this compound in ruminants, it was decided here to prepare a controlled release carrier for thymol. Hydroxy propyl methyl cellulose (HPMC) and ethyl cellulose (EC) were used as the matrix polymer here. Mixtures of thymol with eight ...
متن کاملDevelopment and Evaluation of Thymol Microparticles Using Cellulose Derivatives as Controlled Release Dosage Form
Thymol, an important and advantageous component of many essential oils, has been applied as an antimicrobial agent in animals. To increase the duration of action of this compound in ruminants, it was decided here to prepare a controlled release carrier for thymol. Hydroxy propyl methyl cellulose (HPMC) and ethyl cellulose (EC) were used as the matrix polymer here. Mixtures of thymol with eight ...
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ژورنال
عنوان ژورنال: Journal of the Korea Academia-Industrial cooperation Society
سال: 2015
ISSN: 1975-4701
DOI: 10.5762/kais.2015.16.11.7838